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In this article, authors suggest that unless countries act now to establish a route to readiness regarding the COVID-19 pandemic, the world will miss this opportunity to greatly reduce future health risks. The COVID-19 pandemic killed 2 million people worldwide in 2020 and cost an estimated US$20 trillion; the world failed this test of preparedness and response. COVID-19 has revealed the inadequacy of public health capacity in many countries as well as of the current global health architecture.

The authors conclude that:

• Progress will require not only more and sustained funding from governments but also better technical capacity and improved operational excellence in public health systems across the globe.
• Strengthening our global health architecture will require country commitment and effective governance, effective use of financing and other resources, strong and accountable global leadership, robust technical support, substantial new funding with efficient financial mechanisms, and rigorous accountability.
• Success will also require a stronger commitment to collaboration and new ways of working together that recognise the reality—so vividly illustrated by the COVID-19 pandemic—of our mutual dependency and of the need for mutual accountability.